Monday, January 23, 2012 at 10:19AM Can you give PPIs in pregnancy? This evidence based review looks at the arguments for and against and suggests the risk to the fetus is minimal.
Majithia R, Johnson DA. Are Proton Pump Inhibitors Safe during Pregnancy and Lactation?: Evidence to Date. Drugs 2012.
Monday, January 23, 2012 at 10:15AM A truly distressing condition is the subject of this paper. Faecal incontinence remains a challenge but new techniques and therapies are slowly changing the whole area and this excellent review should be read by primary care physicians especially. The second paper cited suggests this may be a far larger problem from that looking at just those who seek treatment.
Halland M, Talley NJ. Fecal incontinence: mechanisms and management. Curr Opin Gastroenterol 2012;28(1):57-62.
Alsheik EH, Coyne T, Hawes SK, Merikhi L, Naples SP, Kanagarajan N, et al. Fecal incontinence: prevalence, severity, and quality of life data from an outpatient gastroenterology practice. Gastroenterol Res Pract 2012;2012:947694.
Monday, January 23, 2012 at 10:11AM Another review paper (in German) looking at the risks and side effect profile of PPIs. Strangely enough for a surgical journal, it thinks the risk/ benefit imbalance means that more fundoplications should be done. Surprise that, isn't it?
von Rahden BH, Scheurlen M, Filser J, Stein HJ, Germer CT. [Newly recognized side-effects of proton pump inhibitors : Arguments in favour of fundoplication for GERD?]. Chirurg 2012;83(1):38-44
Friday, January 13, 2012 at 11:43AM If one finds Helicobacter during an endoscopy, one is honour bound to treat it no matter what the reason was for the examination. So far not controversial but could one of the reasons for not testing for Helicobacter in GORD be that the very treatment makes it worse?
This paper from the USA highlights a meta analysis of the effect of H. Pylori on the symptomatic and endoscopic changes of GORD. It found that treatment did not make it worse and and may even improve symptoms. Does this reflect what you all see?
Saad AM, Choudhary A, Bechtold ML. Effect of Helicobacter pylori treatment on gastroesophageal reflux disease (GERD): meta-analysis of randomized controlled trials. Scand J Gastroenterol Jan 10 2012.